Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.59 |
| ▸ | CDK8 | P49336 | 6/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | ROS1 | P08922 | 2/20 | 0.53 |
| ▸ | FER | P16591 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | MARK3 | P27448 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165830 | 0.84 | CDK8 (0.49) | RIPK1CDK8AXLPIK3C3CDK7 | |
| SCHEMBL20397075 | 0.80 | PIK3CA (0.61) | RIPK1CDK8AXLPIK3C3CDK7 | |
| SCHEMBL5550017 | 0.79 | PIK3C3 (0.45) | RIPK1CDK8AXLPIK3C3CDK7 | |
| SCHEMBL17938879 | 0.78 | CDK8 (0.77) | CDK8AXLCDK7PLK4ROCK2 | |
| SCHEMBL4831501 | 0.78 | CDK8 (0.81) | RIPK1CDK8AXLCDK7PLK4 | |
| SCHEMBL3499511 | 0.76 | KIT (0.61) | RIPK1CDK8AXLPIK3C3CDK7 | |
| SCHEMBL4154994 | 0.75 | AXL (0.45) | RIPK1CDK8AXLDYRK1BDYRK1A | |
| SCHEMBL858525 | 0.74 | RIPK1 (1.00) | RIPK1CDK8AXLPIK3C3CDK7 | |
| SCHEMBL22978455 | 0.74 | RIPK1 (1.00) | RIPK1CDK8AXLCDK7PLK4 | |
| SCHEMBL15871324 | 0.74 | RIPK1 (0.71) | RIPK1CDK8AXLCDK7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | RIPK1 143/4885CDK8 525/4885AXL 1542/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | RIPK1 161/4885CDK8 639/4885AXL 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.