Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 16/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 14/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155429 | 0.78 | CYP19A1 (0.48) | CYP11B2CYP19A1CYP11B1CYP17A1ALDH1A1 | |
| SCHEMBL10960411 | 0.76 | CYP2A6 (0.50) | CYP11B2CYP19A1CYP11B1CYP17A1ALDH1A1 | |
| SCHEMBL4159796 | 0.73 | MIF (0.44) | CYP11B2CYP19A1CYP11B1MIFPKM | |
| SCHEMBL894805 | 0.73 | ERN1 (0.57) | CYP11B2CYP19A1CYP11B1ALDH1A1KMT2A | |
| SCHEMBL30026143 | 0.71 | CYP2A6 (0.70) | CYP11B2CYP19A1CYP11B1CYP17A1ALDH1A1 | |
| SCHEMBL20541087 | 0.71 | CYP2A6 (0.70) | CYP11B2CYP19A1CYP11B1CYP17A1ALDH1A1 | |
| Fluorene SCHEMBL28302102 | 0.71 | CYP11B1 (0.53) | CYP11B2CYP19A1CYP11B1CYP17A1ALDH1A1 | |
| SCHEMBL4820412 | 0.70 | CYP2A6 (0.47) | CYP11B1ALDH1A1NPY5RCYP1A2CYP3A4 | |
| SCHEMBL10022099 | 0.70 | CYP2A6 (0.47) | CYP11B2CYP19A1CYP11B1ALDH1A1CYP1A2 | |
| SCHEMBL7930734 | 0.70 | CYP2A6 (0.47) | CYP11B1ALDH1A1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | COGHLAN MICHAEL JOSEPH | 2009-06-11 | — | — | US | disclosed |
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | COGHLAN MICHAEL JOSEPH | 2009-06-11 | — | — | US | disclosed |
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | COGHLAN MICHAEL JOSEPH | 2009-06-11 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2006-03-23 | — | — | US | disclosed |
| WO-2004052847-A2 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | NR5A1, NR3C2, NR3C1 | CYP11B2 15/4885CYP19A1 44/4885CYP11B1 14/4885 |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | NR5A1, NR3C2, NR3C1 | CYP11B2 17/4885CYP19A1 44/4885CYP11B1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.