Sugi Predict

Sugi Predict / Compounds / SCHEMBL4167809

SCHEMBL4167809

SCHEMBL4167809

CCOC(=O)COc1ccccc1C(C)=O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 1/20 0.64
▸ USP2 O75604 1/20 0.57
▸ LMNA P02545 7/20 0.57
▸ SMN1; SMN2 Q16637 4/20 0.57
▸ ALDH1A1 P00352 3/20 0.57
▸ KDM4E B2RXH2 2/20 0.57
▸ MAPT P10636 4/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.56
▸ NPC1 O15118 2/20 0.54
▸ RAB9A P51151 2/20 0.54
▸ CASP3 P42574 1/20 0.53
▸ CASP7 P55210 1/20 0.53
▸ CASP9 P55211 1/20 0.53
▸ PTPN1 P18031 1/20 0.52
▸ S1PR4 O95977 1/20 0.52
▸ ITGA4 P13612 1/20 0.52
▸ HPGD P15428 1/20 0.52
▸ S1PR1 P21453 1/20 0.52
▸ MAPK1 P28482 1/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20150685 0.87 ABCB1 (0.64) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL8008468 0.87 ABCB1 (0.64) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL9713678 0.87 ABCB1 (0.68) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL2010417 0.86 USP2 (0.67) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL7455355 0.86 ABCB1 (0.63) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL18702668 0.86 ABCB1 (0.71) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL10742748 0.84 LMNA (0.58) ABCB1LMNASMN1; SMN2ALDH1A1KDM4E
SCHEMBL7897849 0.84 ABCB1 (0.61) ABCB1USP2LMNASMN1; SMN2ALDH1A1
SCHEMBL11286223 0.83 LMNA (0.60) ABCB1LMNASMN1; SMN2ALDH1A1KDM4E
SCHEMBL29938478 0.83 LMNA (0.60) ABCB1LMNASMN1; SMN2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110655464-B Chalcone compound with oxyacetic acid structure and application thereof 肇庆学院 2022-10-21 — — CN disclosed
CN-110179777-B Pharmaceutical compositions comprising nitroxyl donors 卡尔迪奥克斯尔制药公司 2022-07-15 — — CN disclosed
US-11304924-B2 Pharmaceutical compositions comprising nitroxyl donors CARDIOXYL PHARMACEUTICALS, INC. (US) 2022-04-19 — — US disclosed
EP-3427728-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS INC (US) 2021-07-07 — — EP disclosed
US-20200163929-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. 2020-05-28 — — US disclosed
US-10548872-B2 Pharmaceutical compositions comprising nitroxyl donors CARDIOXYL PHARMACEUTICALS, INC. (US) 2020-02-04 — — US disclosed
CN-110655464-A Chalcone compound with oxyacetic acid structure and application thereof 肇庆学院 2020-01-07 — — CN disclosed
US-20190224159-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. 2019-07-25 — — US disclosed
US-10245249-B2 Pharmaceutical compositions comprising nitroxyl donors CARDIOXYL PHARMACEUTICALS, INC. (US) 2019-04-02 — — US disclosed
EP-3427728-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS Cardioxyl Pharmaceuticals, Inc. (US) 2019-01-16 — — EP disclosed
EP-2945621-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS INC (US) 2018-10-17 — — EP disclosed
US-20150366977-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. 2015-12-24 — — US disclosed
EP-2945621-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS Cardioxyl Pharmaceuticals, Inc. (US) 2015-11-25 — — EP disclosed
WO-2014113700-A9 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. (US) 2014-10-09 — — WO disclosed
WO-2014113700-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS CARDIOXYL PHARMACEUTICALS, INC. (US) 2014-07-24 — — WO disclosed
WO-2009085256-A1 ANTI-HIV COMPOUNDS PANACOS PHARMACEUTICALS, INC. (US) 2009-07-09 — — WO disclosed
WO-2009085256-A1 ANTI-HIV COMPOUNDS PANACOS PHARMACEUTICALS, INC. (US) 2009-07-09 — — WO disclosed
US-3994731-A YELLOW, MAGENTA, AND CYAN DEVELOPERS FUJI PHOTO FILM CO., LTD. (JA) 1976-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10548872-B2 Pharmaceutical compositions comprising nitroxyl donors TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885
US-10245249-B2 Pharmaceutical compositions comprising nitroxyl donors TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885
US-20200163929-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885
US-20150366977-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885
US-11304924-B2 Pharmaceutical compositions comprising nitroxyl donors TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885
US-20190224159-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS TNNT2, TNNI3, NQO1 ABCB1 158/4885USP2 1033/4885LMNA 3141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.