Euphorbol

Euphorbol

SCHEMBL4169151

C=C(CC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)C1CC3)C(C)C

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRYAB P02511 5/20 0.71
USP2 O75604 2/20 0.71
ALDH1A1 P00352 2/20 0.71
CYP3A4 P08684 2/20 0.71
MAPT P10636 2/20 0.71
ALOX15 P16050 2/20 0.71
LMNA P02545 1/20 0.71
CRYAA P02489 1/20 0.69
PTGES O14684 2/20 0.58
FNTA P49354 2/20 0.52
FNTB P49356 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Euphorbol SCHEMBL3231975 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Euphorbol SCHEMBL568715 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Euphorbol SCHEMBL4169147 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Euphorbol SCHEMBL28641448 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Euphorbol SCHEMBL17825561 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Euphorbol SCHEMBL7194852 1.00 CRYAB (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Eburicol SCHEMBL29398158 0.90 CRYAB (0.57) CRYABUSP2ALDH1A1CYP3A4MAPT
Eburicoic Acid SCHEMBL24821085 0.90 PTGES (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Eburicoic Acid SCHEMBL24821079 0.90 PTGES (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT
Eburicoic Acid SCHEMBL24821073 0.90 PTGES (0.71) CRYABUSP2ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109294730-B Production of long-chain polyunsaturated fatty acids in plant cells 联邦科学技术研究组织 2021-09-21 CN disclosed
US-9017736-B2 Method of transforming into genin and sapogenins of particular plant species of the family Sapotaceae with the use of exogenous ß-glycosidases for the preparation of cosmetics and dermatological compositions DE LA LLATA ROMERO LUIS (MX) 2015-04-28 US disclosed
US-8545900-B2 Method of obtaining total fixed lipids from seeds of the sapotaceae family, for the preparation of cosmetics and dermatological pharmaceutical compositions DE LA LLATA ROMERO LUIS (MX) 2013-10-01 US disclosed
US-20090197839-A1 Method of obtaining total fixed lipids from seeds of the sapodilla family, for the preparation of cosmetics and dermatological pharmaceutical compositions ROMERO LUIS DE LA LLATA 2009-08-06 US disclosed
US-20090104295-A1 Agent for Hair Growth KOHNO KENJI 2009-04-23 US disclosed
US-20080261291-A1 Method of Obtaining Cyanogenic Glycoside and Related Glycosides, as Well as Genin and Sapogenins Derivatives of Plants of the Family Sapotaceae for the Preparation of Cosmetics and Dermatological Compositions DE LA LLATA ROMERO LUIS 2008-10-23 US disclosed
EP-1915997-A1 AGENT FOR HAIR GROWTH KOHNO, Kenji (JP) 2008-04-30 EP disclosed
WO-2006009417-A1 METHOD OF OBTAINING TOTAL FIXED LIPIDS FROM SEEDS OF THE SAPODILLA FAMILY, FOR THE PREPARATION OF COSMETICS AND DERMATOLOGICAL PHARMACEUTICAL COMPOSITIONS DE LA LLATA ROMERO, MANUEL (MX) 2006-01-26 WO disclosed
WO-2006009418-A1 METHOD OF OBTAINING CYANOGENIC GLYCOSIDES AND RELATED GLYCOSIDES, AS WELL AS GENIN AND SAPOGENIN DERIVATIVES OF PLANTS OF THE SAPODILLA FAMILY, FOR THE PREPARATION OF COSMETICS AND DERMATOLOGICAL COMPOSITIONS DE LA LLATA ROMERO LUIS (MX) 2006-01-26 WO disclosed