SCHEMBL4169804

SCHEMBL4169804

C#Cc1ccc(N)c(N)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.44
TDP1 Q9NUW8 3/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP3A4 P08684 2/20 0.40
ALOX15 P16050 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 1/20 0.40
THRB P10828 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA9 Q16790 2/20 0.38
CA14 Q9ULX7 2/20 0.38
CA4 P22748 1/20 0.38
HDAC8 Q9BY41 3/20 0.37
CDC7 O00311 1/20 0.37
CDK2 P24941 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31338515 1.00 NR4A1 (0.44) NR4A1TDP1MEN1KMT2ACYP3A4
Hydrochloric Acid SCHEMBL18493517 0.97 NR4A1 (0.42) NR4A1TDP1MEN1KMT2ACYP3A4
SCHEMBL689115 0.80 PTPN1 (0.41) CA12CA1CA2CA9CA14
SCHEMBL689815 0.80 PTPN1 (0.41) NR4A1MEN1KMT2ACYP3A4SMN1; SMN2
SCHEMBL17730368 0.78 ALDH1A1 (0.50) ALDH1A1CA12CA1CA2CA9
SCHEMBL4439736 0.78 ALOX15 (0.50) TDP1MEN1KMT2ACYP3A4ALOX15
SCHEMBL2810033 0.78 CYP3A4 (0.50) TDP1MEN1KMT2ACYP3A4ALOX15
SCHEMBL3379669 0.78 TSHR (0.50) TDP1CYP3A4ALOX15SMN1; SMN2TP53
SCHEMBL30362289 0.78 CYP3A4 (0.50) TDP1MEN1KMT2ACYP3A4ALOX15
SCHEMBL14482193 0.78 ALDH1A1 (0.34) TDP1ALDH1A1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11005108-B2 Molecularly tunable heterogeneous catalysts by edge functionalization of graphitic carbons MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2021-05-11 US disclosed
WO-2017031050-A1 MOLECULARLY TUNABLE HETEROGENEOUS CATALYSTS BY EDGE FUNCTIONALIZATION OF GRAPHITIC CARBONS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2017-02-23 WO disclosed
US-20170047592-A1 MOLECULARLY TUNABLE HETEROGENEOUS CATALYSTS BY EDGE FUNCTIONALIZATION OF GRAPHITIC CARBONS UNITED STATES DEPARTMENT OF ENERGY 2017-02-16 US disclosed
WO-2013059281-A2 PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES ENANTA PHARMACEUTICALS, INC. (US) 2013-04-25 WO disclosed
US-20090004508-A1 Thin-film materials, thin films and producing method thereof DAICEL CHEMICAL INDUSTRIES, LTD. 2009-01-01 US disclosed
US-20090004508-A1 Thin-film materials, thin films and producing method thereof DAICEL CHEMICAL INDUSTRIES, LTD. 2009-01-01 US disclosed
US-20090004508-A1 Thin-film materials, thin films and producing method thereof DAICEL CHEMICAL INDUSTRIES, LTD. 2009-01-01 US disclosed
EP-2003123-A2 Thin-film materials, thin films and producing method thereof Daicel Chemical Industries, Ltd. (JP) 2008-12-17 EP disclosed
EP-2003123-A2 Thin-film materials, thin films and producing method thereof Daicel Chemical Industries, Ltd. (JP) 2008-12-17 EP disclosed
US-4005144-A ENDCAPPING HETEROCYCLIC OLIGOMERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1977-01-25 US disclosed
US-3975444-A ENDCAPPING THE UNITES STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1976-08-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170047592-A1 MOLECULARLY TUNABLE HETEROGENEOUS CATALYSTS BY EDGE FUNCTIONALIZATION OF GRAPHITIC CARBONS APEX1, SCO2, EHMT2 NR4A1 3648/4885TDP1 2009/4885MEN1 3448/4885
US-20090004508-A1 Thin-film materials, thin films and producing method thereof RASSF2, NRAS, RASSF5 NR4A1 1994/4885TDP1 3637/4885MEN1 244/4885
US-11005108-B2 Molecularly tunable heterogeneous catalysts by edge functionalization of graphitic carbons APEX1, SCO2, EHMT2 NR4A1 3648/4885TDP1 2009/4885MEN1 3448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.