Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17689140 | 0.84 | SMN1; SMN2 (0.62) | MAPK1POLBTSHRSMN1; SMN2HTT | |
| SCHEMBL7901708 | 0.82 | GAA (0.52) | MAPK1POLBTSHRLMNAPTGS1 | |
| SCHEMBL5747361 | 0.81 | HSD17B10 (0.44) | MAPK1POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL66188 | 0.81 | TSHR (0.70) | MAPK1POLBTSHRALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27738672 | 0.81 | CASR (0.47) | MAPK1POLBTSHRALDH1A1MAPT | |
| SCHEMBL1489970 | 0.79 | TSHR (0.53) | MAPK1POLBTSHRALDH1A1MAPT | |
| SCHEMBL4609862 | 0.79 | HTT (0.49) | MAPK1ALDH1A1SMN1; SMN2HTTNPSR1 | |
| SCHEMBL4180377 | 0.79 | TSHR (0.56) | MAPK1POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5012595 | 0.78 | SMN1; SMN2 (0.59) | MAPK1POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL739939 | 0.78 | LMNA (0.55) | MAPK1POLBTSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101404987-A | Use of sulfonamide derivatives for the treatment of disorders of the surrogate and nervous systems | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | CN | disclosed |
| US-20090069302-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | US | disclosed |
| EP-1976498-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007127505-A2 | USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF DISORDERS OF THE METABOLISM AND THE NERVOUS SYSTEM | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069302-A1 | CHEMICAL COMPOUNDS | TBXA2R, PDE4D, PDE4A | MAPK1 1720/4885POLB 4819/4885TSHR 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.