Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3539558 | 0.93 | HDAC3 (0.38) | HDAC3HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL3546180 | 0.80 | MEN1 (0.43) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL3542118 | 0.78 | MEN1 (0.33) | HDAC1MEN1KMT2A | |
| SCHEMBL3545008 | 0.77 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL3546883 | 0.75 | HSD17B1 (0.37) | KDM4EHDAC3HDAC1HDAC6 | |
| SCHEMBL3543306 | 0.75 | CRHR1 (0.35) | MEN1KMT2ACYP2D6 | |
| SCHEMBL3542239 | 0.75 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL3944499 | 0.73 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL3537452 | 0.72 | ABL1 (0.35) | MEN1KMT2A | |
| SCHEMBL3542236 | 0.70 | PDCD1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |