Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | IL1B | P01584 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CASK | O14936 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | SELP | P16109 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180416 | 0.90 | MAPT (0.33) | P2RX7IL1BMAPK1TYRO3RORC | |
| SCHEMBL4179572 | 0.87 | P2RX7 (0.37) | P2RX7IL1BMPLMAPK1HSD11B1 | |
| SCHEMBL3941725 | 0.83 | P2RY12 (0.39) | P2RX7MPLMAPK1HSD11B1RORC | |
| SCHEMBL4172553 | 0.83 | NOTUM (0.36) | P2RX7MPLRORCKDM4EUSP2 | |
| SCHEMBL4742022 | 0.82 | OPRK1 (0.39) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL4164145 | 0.82 | MPL (0.37) | P2RX7MPLMAPK1HSD11B1CNR2 | |
| SCHEMBL4741483 | 0.81 | OPRK1 (0.38) | P2RX7KDM4EUSP2HPGDNPSR1 | |
| SCHEMBL3929514 | 0.79 | P2RY12 (0.39) | MAPK1KDM4EHPGDHSD17B10 | |
| SCHEMBL3934546 | 0.78 | P2RX7 (0.32) | P2RX7MPLMAPK1CNR2RORC | |
| SCHEMBL4161653 | 0.77 | TNF (0.32) | P2RX7IL1BMAPK1TYRO3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | P2RY12, P2RY11, P2RY1 | P2RX7 5/4885IL1B 481/4885MPL 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.