Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | CASK | O14936 | 2/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | SELP | P16109 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170288 | 0.90 | P2RX7 (0.38) | P2RX7IL1BMAPK1RORCTYRO3 | |
| SCHEMBL4161653 | 0.88 | TNF (0.32) | MAPTP2RX7IL1BMAPK1ITGB2 | |
| SCHEMBL4165173 | 0.86 | OPRK1 (0.35) | MAPTMAPK1RORCALDH1A1MALT1 | |
| SCHEMBL4171958 | 0.86 | MAPK1 (0.35) | MAPTMAPK1RORCALDH1A1NPC1 | |
| SCHEMBL4169013 | 0.86 | RORC (0.34) | MAPTMAPK1ITGB2ICAM1ITGAL | |
| SCHEMBL4179105 | 0.85 | P2RY12 (0.34) | MAPTMAPK1RORCALDH1A1NPC1 | |
| SCHEMBL4892954 | 0.85 | MAPT (0.39) | MAPTALDH1A1NPC1KDM4EMEN1 | |
| SCHEMBL4805982 | 0.84 | OPRK1 (0.35) | MAPTRORCMALT1KMT2A | |
| SCHEMBL4183735 | 0.84 | MAPT (0.33) | MAPTMAPK1ITGB2ICAM1ITGAL | |
| SCHEMBL4178703 | 0.81 | ALDH1A1 (0.37) | MAPTMAPK1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018166-A1 | New Pyridine Analogues X 161 | P2RY12, P2RY11, P2RY1 | MAPT 3645/4885P2RX7 5/4885IL1B 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.