Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219307 | 0.94 | KMT2A (0.42) | POLBTDP1KMT2AMEN1CNR2 | |
| SCHEMBL4170417 | 0.92 | POLB (0.34) | POLBTDP1KMT2AMEN1CNR2 | |
| SCHEMBL3229446 | 0.86 | POLB (0.55) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL3227781 | 0.86 | KMT2A (0.41) | POLBTDP1KMT2AMEN1CNR2 | |
| SCHEMBL3223456 | 0.80 | HSP90AA1 (0.48) | POLBTDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4251171 | 0.78 | TAS1R3 (0.40) | POLBTDP1KMT2AMEN1CNR2 | |
| SCHEMBL3219302 | 0.78 | EPHX2 (0.40) | POLBTDP1KMT2AMEN1CNR2 | |
| SCHEMBL3223065 | 0.78 | POLB (0.51) | POLBKMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL3232905 | 0.77 | POLB (0.52) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL3959135 | 0.77 | KMT2A (0.38) | POLBTDP1KMT2AMEN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079678-A2 | SELECTIVE TR-BETA 1 AGONIST | Cadila Healthcare Limited (IN) | 2009-07-22 | — | — | EP | claimed |
| WO-2008062469-A2 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | claimed |