Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170419 | 0.92 | POLB (0.41) | POLBTDP1MEN1KMT2ACNR2 | |
| SCHEMBL3219302 | 0.89 | EPHX2 (0.40) | POLBTDP1MEN1KMT2ACNR2 | |
| SCHEMBL3219307 | 0.86 | KMT2A (0.42) | POLBTDP1MEN1KMT2ACNR2 | |
| SCHEMBL3229441 | 0.83 | POLB (0.50) | POLBALDH1A1RAB9AMAPTHTT | |
| SCHEMBL3229446 | 0.79 | POLB (0.55) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL3227781 | 0.79 | KMT2A (0.41) | POLBTDP1MEN1KMT2ACNR2 | |
| SCHEMBL3223452 | 0.77 | HSP90AA1 (0.46) | POLBTDP1MEN1KMT2AEPHX2 | |
| SCHEMBL3223456 | 0.73 | HSP90AA1 (0.48) | POLBTDP1MEN1KMT2AEPHX2 | |
| SCHEMBL3216075 | 0.72 | THRB (0.36) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL4251171 | 0.72 | TAS1R3 (0.40) | POLBTDP1MEN1KMT2ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079678-A2 | SELECTIVE TR-BETA 1 AGONIST | Cadila Healthcare Limited (IN) | 2009-07-22 | — | — | EP | claimed |
| WO-2008062469-A2 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | claimed |