Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181488 | 0.96 | NPC1 (0.47) | DRD2DRD3NPC1ADRA2AADRA2B | |
| SCHEMBL4009744 | 0.79 | DRD2 (0.43) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL29730608 | 0.79 | DRD2 (0.43) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL4173286 | 0.79 | ADRA2A (0.46) | DRD2DRD3ADRA2AADRA2BADRA2C | |
| SCHEMBL4167674 | 0.79 | ADRA2A (0.40) | DRD2DRD3NPC1ADRA2AADRA2B | |
| SCHEMBL29222780 | 0.79 | PNMT (0.38) | DRD2DRD3NPC1HTR2AHTR2C | |
| SCHEMBL15025246 | 0.77 | DRD3 (0.45) | DRD2DRD3HTR2AHTR2CGRM5 | |
| SCHEMBL14149272 | 0.75 | ADRA2A (0.40) | DRD2DRD3NPC1ADRA2AADRA2B | |
| SCHEMBL13482129 | 0.74 | GRM5 (0.44) | NPC1MAOAGRM5POLBTDP1 | |
| SCHEMBL4774263 | 0.74 | DRD2 (0.43) | DRD2DRD3ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023774-A1 | Pyridine analogs as C5A antagonists | LACHANCE NICOLAS | 2009-01-22 | — | — | US | disclosed |
| US-20090023774-A1 | Pyridine analogs as C5A antagonists | LACHANCE NICOLAS | 2009-01-22 | — | — | US | disclosed |
| US-20090023774-A1 | Pyridine analogs as C5A antagonists | LACHANCE NICOLAS | 2009-01-22 | — | — | US | disclosed |
| US-7429666-B2 | antiinflammatory agents; N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-2-methoxy-5,6,7,8-tetrahydroquinoline-8-carboxamide | MERCK FROSST CANADA LTD. (CA) | 2008-09-30 | — | — | US | disclosed |
| US-7429666-B2 | antiinflammatory agents; N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-2-methoxy-5,6,7,8-tetrahydroquinoline-8-carboxamide | MERCK FROSST CANADA LTD. (CA) | 2008-09-30 | — | — | US | disclosed |
| US-7429666-B2 | antiinflammatory agents; N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-2-methoxy-5,6,7,8-tetrahydroquinoline-8-carboxamide | MERCK FROSST CANADA LTD. (CA) | 2008-09-30 | — | — | US | disclosed |
| EP-1758865-A1 | PYRIDINE ANALOGS AS C5A ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121095-A1 | PYRIDINE ANALOGS AS C5A ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2005-12-22 | — | — | WO | disclosed |
| US-20050277644-A1 | antiinflammatory agents; N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-2-methoxy-5,6,7,8-tetrahydroquinoline-8-carboxamide | MERCK FROSST CANADA LTD. (CA) | 2005-12-15 | — | — | US | disclosed |
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| EP-0946523-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028281-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277644-A1 | antiinflammatory agents; N-[4-(Dimethylamino)benzyl]-N-(4-isopropylphenyl)-2-methoxy-5,6,7,8-tetrahydroquinoline-8-carboxamide | C5AR2, C5AR1, C3AR1 | DRD2 2090/4885DRD3 3077/4885NPC1 1437/4885 |
| US-20090023774-A1 | Pyridine analogs as C5A antagonists | C5AR1, C3AR1, C5AR2 | DRD2 2845/4885DRD3 3408/4885NPC1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.