SCHEMBL4170987

SCHEMBL4170987

O=C(O)N1CCN(C(=O)c2cccc(Br)c2)C(COc2cccnc2)C1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
KDM4E B2RXH2 2/20 0.46
HTT P42858 1/20 0.45
TP53 P04637 1/20 0.43
GRIN2C Q14957 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
CHRNA1 P02708 1/20 0.41
CHRNB1 P11230 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA7 P36544 1/20 0.41
CHRNA4 P43681 1/20 0.41
CHRNB3 Q05901 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3930902 0.89 NPSR1 (0.48) CHRNA1CHRNB1CHRNB2CHRNB4CHRNA3
SCHEMBL780353 0.88 KDM4E (0.46) ALDH1A1KDM4EGRIN2CCHRNA1CHRNB1
SCHEMBL778560 0.82 CHRNA7 (0.57) CHRNA7
SCHEMBL3930962 0.81 ALDH1A1 (0.43) ALDH1A1KMT2ACHRNA1CHRNB1CHRNB2
SCHEMBL15841933 0.81 RECQL (0.47) KMT2ACHRNA1CHRNB1CHRNB2CHRNB4
Hydrochloric Acid SCHEMBL780044 0.81 KCNH2 (0.58)
SCHEMBL4010198 0.80 CHRNA1 (0.41) CHRNA1CHRNB1CHRNB2CHRNB4CHRNA3
SCHEMBL3934162 0.79 CHRNA7 (0.46) CHRNA1CHRNB1CHRNB2CHRNB4CHRNA3
SCHEMBL3931014 0.78 DRD2 (0.41) CHRNA1CHRNB1CHRNB2CHRNB4CHRNA3
SCHEMBL3930577 0.78 CHRNA1 (0.40) CHRNA1CHRNB1CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044038-A2 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF Cornerstone Therapeutics Inc. (US) 2009-04-08 EP disclosed
WO-2007146066-A2 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF CRITICAL THERAPEUTICS, INC. (US) 2007-12-21 WO disclosed