SCHEMBL4171348

SCHEMBL4171348

Cn1nc(C(F)(F)F)c(CSc2ncc([Si](C)(C)C)s2)c1OCC(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.32
MAPT P10636 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32
MPO P05164 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4164764 0.87 MEN1 (0.31) MEN1KMT2ASMN1; SMN2MPO
SCHEMBL4161956 0.85 MPO (0.31) MEN1KMT2ASMN1; SMN2MPO
SCHEMBL4171206 0.82 MEN1 (0.35) L3MBTL1MEN1KMT2ASMN1; SMN2
SCHEMBL4171295 0.82 MEN1 (0.35) L3MBTL1MEN1KMT2ASMN1; SMN2
SCHEMBL4172815 0.80 KDM4E (0.38) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL4161947 0.79 PKM (0.36) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL4171943 0.76 MAPT (0.31) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL4169700 0.75 MEN1 (0.36) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL1027343 0.75 MPO (0.33) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL2890776 0.74 MEN1 (0.31) MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090048112-A1 Novel Herbicides SYNGENTA LIMITED (GB) 2009-02-19 US disclosed
US-20090048112-A1 Novel Herbicides SYNGENTA LIMITED (GB) 2009-02-19 US disclosed
EP-1885720-A2 4-(THIAZOL-2-YLTHIOALKYL)-PYRAZOLES AND THEIR USE AS HERBICIDES Syngenta Limited (GB) 2008-02-13 EP disclosed
WO-2006123088-A2 4- (THIAZOL-2-YLTHIOALKYL) -PYRAZOLES AND THEIR USE AS HERBICIDES SYNGENTA LIMITED (GB) 2006-11-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048112-A1 Novel Herbicides HAX1, MTX1, CYP4X1 L3MBTL1 927/4885MAPT 4688/4885MEN1 1520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.