Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 5/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.30 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529588 | 0.81 | GSK3B (0.33) | KDM4EGSK3BCYP1A2SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4175924 | 0.81 | KDM4E (0.42) | KDM4EGSK3BKCNH2KMT2ATOP2A | |
| Trifluoroacetic Acid SCHEMBL4164839 | 0.80 | KDM4E (0.35) | KDM4EGSK3BKCNH2KMT2ATOP1 | |
| SCHEMBL4186330 | 0.80 | SIGMAR1 (0.36) | KDM4EGSK3BKMT2ACYP2D6 | |
| SCHEMBL4186321 | 0.80 | SIGMAR1 (0.36) | KDM4EGSK3BKMT2ACYP2D6 | |
| Trifluoroacetic Acid SCHEMBL3976871 | 0.77 | KDM4E (0.38) | KDM4EGSK3BALDH1A1DRD3CYP1A2 | |
| SCHEMBL4144519 | 0.75 | KDM4E (0.36) | KDM4EKMT2ATOP2AALDH1A1CYP1A2 | |
| SCHEMBL4886270 | 0.74 | KDM4E (0.43) | KDM4EGSK3BKCNH2KMT2ATOP2A | |
| SCHEMBL4879938 | 0.73 | CNR1 (0.41) | KDM4EGSK3BKCNH2KMT2ATOP1 | |
| SCHEMBL4175956 | 0.72 | KDM4E (0.37) | KDM4EGSK3BKCNH2TOP1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1824871-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050940-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885GSK3B 2763/4885KCNH2 1548/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | KDM4E 4136/4885GSK3B 3177/4885KCNH2 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.