Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790226 | 0.86 | PPARG (0.43) | KMT2AHRH3KCNH2 | |
| SCHEMBL4791994 | 0.81 | PTAFR (0.41) | HRH3KCNH2 | |
| SCHEMBL4167425 | 0.77 | ESR1 (0.47) | HRH3KCNH2 | |
| SCHEMBL4175289 | 0.74 | HRH3 (0.46) | HSD17B10HTTHRH3KCNH2 | |
| SCHEMBL4155158 | 0.73 | HPGD (0.43) | HPGDTP53MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4170563 | 0.70 | HPGD (0.42) | HPGDTHRBTP53MAPTALDH1A1 | |
| SCHEMBL4793844 | 0.70 | HRH3 (0.39) | SMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL3844239 | 0.70 | NPC1 (0.36) | — | |
| SCHEMBL4762113 | 0.70 | CDK9 (0.43) | SMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL1813182 | 0.69 | HRH3 (0.76) | HPGDALDH1A1MGLLHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | disclosed |