Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155158 | 0.84 | HPGD (0.43) | HPGDALDH1A1MAPTTP53FGFR1 | |
| SCHEMBL3844239 | 0.80 | NPC1 (0.36) | RAB9A | |
| SCHEMBL4793844 | 0.73 | HRH3 (0.39) | ALDH1A1RAB9A | |
| SCHEMBL20603947 | 0.71 | FGFR1 (0.67) | HPGDTHRBFGFR1GSK3BRAB9A | |
| SCHEMBL4762113 | 0.71 | CDK9 (0.43) | ALDH1A1 | |
| SCHEMBL4172886 | 0.70 | HPGD (0.44) | HPGDALDH1A1MAPTTP53THRB | |
| SCHEMBL4167425 | 0.69 | ESR1 (0.47) | — | |
| SCHEMBL121454 | 0.67 | FGFR1 (0.76) | HPGDALDH1A1THRBMGLLFGFR1 | |
| SCHEMBL1812407 | 0.67 | MGLL (0.57) | HPGDALDH1A1MGLL | |
| SCHEMBL4792135 | 0.67 | HDAC6 (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | disclosed |