Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762113 | 0.94 | CDK9 (0.43) | HRH3SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL4792853 | 0.87 | CDK9 (0.38) | HRH3SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL4762035 | 0.83 | HDAC1 (0.39) | HRH3SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL4791558 | 0.83 | HRH3 (0.37) | HRH3SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL4155158 | 0.80 | HPGD (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4790226 | 0.76 | PPARG (0.43) | HRH3HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL4791994 | 0.76 | PTAFR (0.41) | HRH3CDK9HDAC1HDAC6HDAC3 | |
| SCHEMBL4170563 | 0.73 | HPGD (0.42) | ALDH1A1RAB9A | |
| SCHEMBL2878939 | 0.73 | HDAC6 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL4792261 | 0.73 | HRH3 (0.52) | HRH3SMN1; SMN2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |