Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4156262 | 0.99 | L3MBTL3 (0.52) | L3MBTL3L3MBTL1ALDH1A1HPGDCHRM1 | |
| Trifluoroacetic Acid SCHEMBL4163494 | 0.97 | L3MBTL3 (0.51) | L3MBTL3L3MBTL1ALDH1A1HPGDCHRM1 | |
| SCHEMBL17707563 | 0.97 | L3MBTL3 (0.56) | L3MBTL3L3MBTL1ALDH1A1HPGDCHRM1 | |
| Trifluoroacetic Acid SCHEMBL2203749 | 0.86 | L3MBTL1 (0.57) | L3MBTL3L3MBTL1ALDH1A1HPGDHDAC6 | |
| SCHEMBL17707597 | 0.82 | L3MBTL3 (0.61) | L3MBTL3L3MBTL1ALDH1A1HPGDHDAC6 | |
| Trifluoroacetic Acid SCHEMBL17707556 | 0.79 | HDAC6 (0.52) | L3MBTL3L3MBTL1ALDH1A1HPGDHDAC6 | |
| Trifluoroacetic Acid SCHEMBL2203401 | 0.77 | HDAC6 (0.50) | L3MBTL3L3MBTL1ALDH1A1HPGDHDAC6 | |
| Trifluoroacetic Acid SCHEMBL2202754 | 0.76 | HDAC6 (0.47) | CHRM1HDAC6HDAC1CYP2C9HDAC3 | |
| SCHEMBL2205027 | 0.74 | P2RX7 (0.55) | L3MBTL3L3MBTL1ALDH1A1HPGDHDAC6 | |
| SCHEMBL2202787 | 0.74 | HDAC6 (0.53) | ALDH1A1HPGDHDAC6HDAC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | claimed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | L3MBTL3 4202/4885L3MBTL1 3739/4885ALDH1A1 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.