Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.60 |
| ▸ | CACNA2D1 | P54289 | 8/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.55 |
| ▸ | CACNB1 | Q02641 | 8/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | RBP4 | P02753 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539165 | 0.89 | SERPINE1 (0.70) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| Hydrochloric Acid SCHEMBL416268 | 0.88 | SERPINE1 (0.68) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1800779 | 0.85 | SERPINE1 (0.65) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1798810 | 0.85 | SERPINE1 (0.84) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1800427 | 0.84 | SERPINE1 (0.64) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1796719 | 0.83 | SERPINE1 (0.63) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1797273 | 0.83 | SERPINE1 (0.51) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1800176 | 0.83 | SERPINE1 (0.51) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1797272 | 0.83 | SERPINE1 (0.51) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL1797787 | 0.80 | SERPINE1 (0.59) | SERPINE1CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607348-B1 | Plasminogen Activator Inhibitor-1 Inhibitor | RENASCIENCE INC (JP) | 2021-03-17 | — | — | EP | disclosed |
| US-20140296256-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | RENASCIENCE CO LTD (JP) | 2014-10-02 | — | — | US | disclosed |
| US-8785473-B2 | Plasminogen activator inhibitor-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2014-07-22 | — | — | US | disclosed |
| EP-2607348-A2 | Plasminogen Activator Inhibitor-1 Inhibitor | Renascience CO., LTD. (JP) | 2013-06-26 | — | — | EP | disclosed |
| EP-2415755-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Renascience CO., LTD. (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20120022080-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | RENASCIENCE CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296256-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | SERPINE1, SERPINC1, SERPINB1 | SERPINE1 1/4885CACNA2D1 4720/4885CACNA1B 4663/4885 |
| US-20120022080-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | SERPINE1 1/4885CACNA2D1 4720/4885CACNA1B 4663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.