Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216831 | 0.92 | CNR2 (0.80) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2215960 | 0.91 | CNR2 (0.79) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2214559 | 0.89 | CNR2 (0.66) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2213176 | 0.87 | CNR2 (0.71) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2212394 | 0.84 | CNR2 (0.94) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL600437 | 0.83 | CNR2 (1.00) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL27891826 | 0.83 | CNR2 (0.92) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2214367 | 0.83 | CNR2 (0.66) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL2215826 | 0.83 | CNR2 (0.56) | CNR2ALDH1A1KDM4EHPGDGABRP | |
| SCHEMBL28868382 | 0.83 | CNR2 (0.98) | CNR2ALDH1A1KDM4EPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD. (CN) | 2009-09-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227619-A1 | Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo | TPH1, HTR1F, TPH2 | CNR2 156/4885ALDH1A1 324/4885MAPT 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.