SCHEMBL4180806

SCHEMBL4180806

O=S(=O)(O)OC[C@H]1O[C@H](O[C@H]2O[C@H](COS(=O)(=O)O)[C@@H](OS(=O)(=O)O)[C@H](OS(=O)(=O)O)[C@H]2OS(=O)(=O)O)[C@H](OS(=O)(=O)O)[C@@H](OS(=O)(=O)O)[C@@H]1OS(=O)(=O)O

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FGF1 P05230 7/20 0.69
FGF2 P09038 5/20 0.69
HPSE Q9Y251 14/20 0.54
SERPINC1 P01008 1/20 0.49
VEGFA P15692 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4904646 0.94 FGF1 (0.70) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL4906384 0.94 FGF1 (0.70) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL14020073 0.94 FGF1 (0.70) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL2528200 0.93 FGF1 (0.62) FGF1FGF2HPSESERPINC1
SCHEMBL2524663 0.93 FGF1 (0.62) FGF1FGF2HPSESERPINC1
SCHEMBL18742104 0.92 FGF1 (0.76) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL18742103 0.92 FGF1 (0.76) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL7311357 0.92 FGF1 (0.76) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL14020078 0.88 FGF1 (0.64) FGF1FGF2HPSESERPINC1VEGFA
SCHEMBL14020081 0.88 FGF1 (0.64) FGF1FGF2HPSESERPINC1VEGFA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090215717-A1 Sulfated oligosaccharides IVAX DRUG RESEARCH INSTITUTE LTD. (HU) 2009-08-27 US claimed
WO-2006017752-A2 SULFATED OLIGOSACCHARIDES IVAX CORPORATION (US) 2006-02-16 WO claimed
EP-1064013-A4 $i(IN VITRO) FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES UNIV WASHINGTON (US) 2005-05-11 EP claimed
EP-1064013-A1 $i(IN VITRO) FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES University of Washington (US) 2001-01-03 EP claimed
WO-1999045947-A9 IN VITRO FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES UNIV WASHINGTON (US) 2000-03-02 WO claimed
WO-1999045947-A1 IN VITRO FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES UNIVERSITY OF WASHINGTON (US) 1999-09-16 WO claimed
US-10299714-B2 Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide BECTON, DICKINSON AND COMPANY (US) 2019-05-28 US disclosed
EP-2645932-B1 BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT BECTON DICKINSON CO (US) 2016-03-02 EP disclosed
EP-2645932-A2 BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT Becton, Dickinson and Company (US) 2013-10-09 EP disclosed
US-20120149004-A1 BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT BECTON, DICKINSON AND COMPANY (US) 2012-06-14 US disclosed
WO-2012075407-A2 BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT BECTON, DICKINSON AND COMPANY (US) 2012-06-07 WO disclosed
US-20090215717-A1 Sulfated oligosaccharides IVAX DRUG RESEARCH INSTITUTE LTD. (HU) 2009-08-27 US disclosed
US-20070078082-A1 Methods and compositions to treat glycosaminoglycan-associated molecular interactions NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2007-04-05 US disclosed
EP-1064013-A1 $i(IN VITRO) FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES University of Washington (US) 2001-01-03 EP disclosed
WO-1999045947-A9 IN VITRO FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES UNIV WASHINGTON (US) 2000-03-02 WO disclosed
WO-2000006133-A2 COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN-ASSOCIATED MOLECULAR INTERACTIONS NEUROCHEM, INC. (CA) 2000-02-10 WO disclosed
WO-1999045947-A1 IN VITRO FORMATION OF CONGOPHILIC MALTESE-CROSS AMYLOID PLAQUES TO IDENTIFY ANTI-PLAQUE THERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S AND PRION DISEASES UNIVERSITY OF WASHINGTON (US) 1999-09-16 WO disclosed
EP-0814842-A1 METHOD FOR TREATING AMYLOIDOSIS Queen's University at Kingston (CA) 1998-01-07 EP disclosed
WO-1996028187-A1 METHOD FOR TREATING AMYLOIDOSIS QUEEN'S UNIVERSITY AT KINGSTON (CA) 1996-09-19 WO disclosed
EP-0230023-B1 PHARMACEUTICAL COMPOSITIONS FOR THE ENHANCEMENT OF WOUND HEALING MARION MERRELL DOW INC. (US) 1992-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149004-A1 BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT FUCA2, HBG1, FUT6 FGF1 1162/4885FGF2 476/4885HPSE 18/4885
US-20070078082-A1 Methods and compositions to treat glycosaminoglycan-associated molecular interactions HPSE, CD44, CSGALNACT1 FGF1 358/4885FGF2 230/4885HPSE 1/4885
US-20090215717-A1 Sulfated oligosaccharides CSGALNACT1, ST3GAL3, ALG1 FGF1 485/4885FGF2 229/4885HPSE 98/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.