SCHEMBL4180992

SCHEMBL4180992

CC(C)Cc1cc(-c2cccc(C=O)c2)c(S(=O)(=O)NC(C)(C)C)s1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 20/20 0.44
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4181608 0.88 AGTR2 (0.46) AGTR2
SCHEMBL4194899 0.82 AGTR2 (0.49) AGTR2
SCHEMBL710338 0.78 AGTR2 (0.51) AGTR2
SCHEMBL1359282 0.77 AGTR2 (0.51) AGTR2
SCHEMBL707086 0.77 AGTR2 (0.48) AGTR2
SCHEMBL1719802 0.76 AGTR2 (0.56) AGTR2
SCHEMBL1718877 0.75 AGTR2 (0.75) AGTR2
SCHEMBL1718934 0.75 AGTR2 (0.56) AGTR2CYP3A4
SCHEMBL1357563 0.74 AGTR2 (0.48) AGTR2
SCHEMBL1718991 0.74 AGTR2 (0.57) AGTR2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869009-B1 NEW BICYCLIC ANGIOTENSIN II AGONISTS VICORE PHARMA AB (SE) 2016-06-01 EP disclosed
US-8357710-B2 Bicyclic angiotensin II agonists VICORE PHARMA AB (SE) 2013-01-22 US disclosed
US-20090069382-A1 Bicyclic Angiotensin II Agonists VICORE PHARMA AB (SE) 2009-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069382-A1 Bicyclic Angiotensin II Agonists AGTR2, AGTR1, BDKRB2 AGTR2 1/4885CYP3A4 777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.