SCHEMBL4181431

SCHEMBL4181431

N#Cc1ccc(NC(=O)C(=O)c2cccs2)cc1C(F)(F)F

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 10/20 0.67
▸ BLM P54132 1/20 0.49
▸ TAS2R14 Q9NYV8 1/20 0.49
▸ SLC22A12 Q96S37 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4178067 0.83 L3MBTL1 (0.59) ARBLMSLC22A12
SCHEMBL4176579 0.81 TAS2R14 (0.58) ARTAS2R14SLC22A12
SCHEMBL24414726 0.80 AR (1.00) AR
SCHEMBL5664793 0.78 AR (0.55) ARTAS2R14
SCHEMBL17658051 0.78 BLM (0.63) ARBLMTAS2R14SLC22A12
SCHEMBL5247689 0.76 TAS2R14 (0.60) ARBLMTAS2R14SLC22A12
SCHEMBL202386 0.76 AR (0.52) ARTAS2R14
SCHEMBL29415541 0.76 AR (0.52) ARTAS2R14
SCHEMBL202266 0.76 AR (0.52) ARBLMTAS2R14
SCHEMBL17664290 0.76 AR (0.55) ARBLMTAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AG (DE) 2009-03-19 — — US disclosed
WO-2008077646-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-07-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090075989-A1 NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS NR5A1, CYP19A1, GPER1 AR 145/4885BLM 3291/4885TAS2R14 2597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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