Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14569802 | 0.80 | KMT2A (0.72) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL463912 | 0.72 | TSHR (0.56) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL2733150 | 0.72 | TSHR (0.65) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL2733147 | 0.72 | TSHR (0.65) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL7806213 | 0.71 | TSHR (0.51) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL416900 | 0.69 | TSHR (0.52) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL464236 | 0.69 | MEN1 (0.52) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL13557184 | 0.67 | KMT2A (0.50) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL8517882 | 0.67 | ATM (0.48) | KMT2AMEN1TSHRALDH1A1ATM | |
| SCHEMBL30561555 | 0.67 | ATM (0.48) | KMT2AMEN1TSHRALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064034-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064034-A1 | Peptidomimetic protease inhibitors | CTSC, PREP, PEPD | KMT2A 3611/4885MEN1 3086/4885TSHR 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.