Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 6/20 | 0.38 |
| ▸ | CSF1R | P07333 | 6/20 | 0.38 |
| ▸ | LYN | P07948 | 6/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 6/20 | 0.38 |
| ▸ | SIK1 | P57059 | 6/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 6/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 6/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178307 | 0.91 | FGFR1 (0.39) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL4183203 | 0.88 | FGFR1 (0.41) | PIM1ABL1FGFR1FGFR2FGFR3 | |
| SCHEMBL4185266 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL4178056 | 0.86 | PGK1 (0.46) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL4191726 | 0.86 | PRMT5 (0.39) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL13929789 | 0.85 | PLAU (0.45) | MAPTCSF1RFGFR1FGFR2FGFR3 | |
| SCHEMBL4187139 | 0.83 | FGFR1 (0.45) | KDM4EALDH1A1LMNAMAPTCSF1R | |
| SCHEMBL4189829 | 0.78 | FGFR3 (0.39) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL3627208 | 0.77 | TDO2 (0.51) | KDM4EALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL4177973 | 0.75 | FGFR1 (0.41) | PIM1ABL1FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090047244-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS I | IDENIX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090047244-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS I | IDENIX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2009014730-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047244-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS I | SERPINB1, SPINT2, PRSS1 | KDM4E 3639/4885ALDH1A1 1406/4885LMNA 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.