⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780181 | 0.65 | — | — | |
| SCHEMBL738003 | 0.65 | — | — | |
| SCHEMBL4498589 | 0.65 | — | — | |
| SCHEMBL136516 | 0.65 | — | — | |
| SCHEMBL555090 | 0.65 | — | — | |
| SCHEMBL6513587 | 0.65 | — | — | |
| SCHEMBL221682 | 0.65 | — | — | |
| SCHEMBL716246 | 0.61 | — | — | |
| SCHEMBL1208064 | 0.61 | — | — | |
| SCHEMBL937095 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104428299-B | 5- azaindazole compounds and its application method | 霍夫曼-拉罗奇有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-102947306-A | 7-(1h-pyrazol-4-yl)-1,6-naphthyridine compounds as SYK inhibitors | GLAXO GROUP LTD | 2013-02-27 | — | — | CN | claimed |
| WO-2008038011-A1 | PYRIMIDINE DERIVATIVES AS AURORA A AND AURORA B INHIBITORS | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | claimed |
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | claimed |
| CN-110036004-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-104428299-B | 5- azaindazole compounds and its application method | 霍夫曼-拉罗奇有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-104428299-A | 5-azaindazole compounds and methods of use | HOFFMANN LA ROCHE | 2015-03-18 | — | — | CN | disclosed |
| CN-102947306-A | 7-(1h-pyrazol-4-yl)-1,6-naphthyridine compounds as SYK inhibitors | GLAXO GROUP LTD | 2013-02-27 | — | — | CN | disclosed |
| EP-2023912-A2 | METHODS AND COMPOSITIONS USING IMMUNOMODULATORY COMPOUNDS IN COMBINATION THERAPY | CELGENE CORPORATION (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008038010-A1 | PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
| WO-2008038011-A1 | PYRIMIDINE DERIVATIVES AS AURORA A AND AURORA B INHIBITORS | VERNALIS (R & D) LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
| WO-2007139939-A2 | METHODS AND COMPOSITIONS USING IMMUNOMODULATORY COMPOUNDS IN COMBINATION THERAPY | CELGENE CORPORATION (US) | 2007-12-06 | — | — | WO | disclosed |
| US-6180355-B1 | Method for diagnosing and treating chronic pelvic pain syndrome | UNIVERSITY OF MARYLAND, BALTIMORE | 2001-01-30 | — | — | US | disclosed |