Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183110 | 1.00 | KDM4E (0.41) | KDM4ELMNACYP2C9ALDH1A1MAPT | |
| SCHEMBL4182866 | 0.89 | KDM4E (0.46) | KDM4ELMNACYP2C9ALDH1A1MAPT | |
| SCHEMBL4182864 | 0.89 | KDM4E (0.46) | KDM4ELMNACYP2C9ALDH1A1MAPT | |
| SCHEMBL4182871 | 0.89 | KDM4E (0.46) | KDM4ELMNACYP2C9ALDH1A1MAPT | |
| SCHEMBL4197695 | 0.88 | ALDH1A1 (0.43) | LMNAALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4197694 | 0.88 | ALDH1A1 (0.43) | LMNAALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13982049 | 0.83 | KDM4E (0.39) | KDM4ELMNACYP2C9ALDH1A1MAPT | |
| SCHEMBL4189717 | 0.82 | ESR2 (0.42) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL4189714 | 0.82 | ESR2 (0.42) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL13927928 | 0.82 | KDM4E (0.39) | KDM4ELMNACYP2C9ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | HTR5A, CRH, CYP17A1 | KDM4E 3317/4885LMNA 1414/4885CYP2C9 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.