Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20367292 | 0.84 | TRPC5 (0.35) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL30328166 | 0.78 | HPGD (0.38) | HTTHPGDHSD17B10 | |
| SCHEMBL23620552 | 0.77 | HPGD (0.56) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL1693503 | 0.77 | HPGD (0.54) | ADORA2BTP53HTTHPGDHSD17B10 | |
| SCHEMBL30031420 | 0.76 | PIK3CA (0.46) | LMNAPOLBHTTHSD17B10TSHR | |
| SCHEMBL7504710 | 0.75 | CDK4 (0.56) | — | |
| SCHEMBL28682158 | 0.75 | TSHR (0.40) | ADORA2ALMNAPOLBHPGDTSHR | |
| SCHEMBL29351994 | 0.75 | TSHR (0.40) | ADORA2ALMNAPOLBHPGDTSHR | |
| SCHEMBL4191402 | 0.74 | PDE4A (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL24572009 | 0.74 | HSD17B10 (0.37) | ADORA2ALMNAHTTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |