Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265319 | 0.76 | LMNA (0.60) | ADORA2AALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL29864436 | 0.76 | LMNA (0.60) | ADORA2AALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1693811 | 0.75 | ADORA3 (0.64) | ALDH1A1HPGDHSD17B10KDM4EADORA3 | |
| SCHEMBL14852954 | 0.74 | CYP1A2 (0.41) | PDE4BMEN1KMT2AADORA3LMNA | |
| SCHEMBL7504710 | 0.74 | CDK4 (0.56) | — | |
| SCHEMBL4184836 | 0.74 | PDE4A (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4191400 | 0.72 | CYP1A2 (0.49) | PDE4BMEN1KMT2APGRADORA3 | |
| SCHEMBL18865521 | 0.72 | ADORA3 (0.51) | ALDH1A1HPGDKDM4EADORA3TLR7 | |
| SCHEMBL29691119 | 0.72 | MTOR (0.51) | ADORA3LMNAUSP1 | |
| SCHEMBL18865616 | 0.72 | MTOR (0.51) | ADORA3LMNAUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |