Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378662 | 0.88 | ALDH1A1 (0.41) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL31300122 | 0.80 | AKR1C3 (0.40) | MEN1KMT2AGAAPTGS2AKR1C3 | |
| SCHEMBL849461 | 0.78 | L3MBTL1 (0.57) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL22001663 | 0.76 | ALDH1A1 (0.32) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL11036457 | 0.75 | KEAP1 (0.40) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL31300116 | 0.74 | GRM2 (0.38) | LMNAKDM4EMAPTGRM2ALOX12 | |
| SCHEMBL14860683 | 0.73 | CRBN (0.49) | ALDH1A1CYP1A2KDM4EGAACRBN | |
| SCHEMBL5666187 | 0.72 | ALDH1A1 (0.41) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6360701 | 0.72 | NPC1 (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL18920701 | 0.71 | ALDH1A1 (0.36) | NPC1RAB9AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009096907-A1 | AZIRIDINE SYNTHESIS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-08-06 | — | — | WO | disclosed |
| US-6100289-A | ADMINISTERING AN ANALGESIC AMOUNT OF EXCITATORY AMINO ACID ANTAGONIST TO MAMMAL | GLAXO WELLCOME SPA (IT) | 2000-08-08 | — | — | US | disclosed |
| US-5962496-A | CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO WELLCOME SPA (IT) | 1999-10-05 | — | — | US | disclosed |
| US-5760059-A | ANTAGONISTS OF EXCITATORY AMINO ACIDS, TREATMENT OF NEURODEGENERATIVE DISEASES | GLAXO WELLCOME SPA (IT) | 1998-06-02 | — | — | US | disclosed |
| EP-0723541-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.p.A. (IT) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010517-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.P.A. (IT) | 1995-04-20 | — | — | WO | disclosed |