Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175101 | 0.87 | SIGMAR1 (0.53) | SIGMAR1GSK3AGSK3BPOLB | |
| SCHEMBL5601152 | 0.76 | KMT2A (0.50) | HTTSLC6A3SIGMAR1GSK3AGSK3B | |
| SCHEMBL1535118 | 0.76 | CYP19A1 (0.57) | SIGMAR1MAPTPOLB | |
| SCHEMBL409741 | 0.75 | HMOX1 (0.72) | HMOX1MAPTPOLBKMT2A | |
| Bromide SCHEMBL29223796 | 0.74 | HMOX1 (0.70) | HMOX1MAPTPOLBKMT2A | |
| Hydrochloric Acid SCHEMBL7527357 | 0.74 | HMOX1 (0.70) | HMOX1MAPTPOLBKMT2A | |
| SCHEMBL28800303 | 0.72 | QPCT (0.44) | HTTHMOX1POLBKMT2AATM | |
| SCHEMBL21198915 | 0.72 | ADORA2A (0.44) | HTTSLC6A3SIGMAR1HMOX1 | |
| SCHEMBL28802435 | 0.71 | HPGDS (0.55) | HTTHMOX1NPC1RAB9ADRD2 | |
| SCHEMBL27706311 | 0.71 | HMOX1 (0.59) | HTTSLC6A3GSK3AGSK3BMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |