Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196161 | 1.00 | HTR1A (0.51) | HTR1ATRPV1GAAHTR1DHTR1B | |
| SCHEMBL4185549 | 0.94 | HTR1A (0.47) | HTR1ATRPV1GAAHTR1DHTR1B | |
| SCHEMBL4185512 | 0.93 | HTR1A (0.55) | HTR1ATRPV1GAAHTR1DHTR1B | |
| SCHEMBL13927905 | 0.86 | HRH3 (0.48) | HTR1ATRPV1 | |
| SCHEMBL13927906 | 0.86 | HRH3 (0.48) | HTR1ATRPV1 | |
| SCHEMBL13927894 | 0.83 | HTR1A (0.53) | HTR1ATRPV1GAAHTR1DHTR1B | |
| SCHEMBL13927892 | 0.83 | HTR1A (0.53) | HTR1ATRPV1GAAHTR1DHTR1B | |
| SCHEMBL21061775 | 0.83 | NR3C2 (0.52) | HTR1ATRPV1GAAHTR1DALDH1A1 | |
| SCHEMBL30541704 | 0.83 | NR3C2 (0.52) | HTR1ATRPV1GAAHTR1DALDH1A1 | |
| SCHEMBL4180037 | 0.81 | HRH3 (0.54) | HTR1ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | HTR5A, CRH, CYP17A1 | HTR1A 77/4885TRPV1 1505/4885GAA 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.