Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 8/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053292 | 0.82 | KDM4E (0.59) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL13909029 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL453628 | 0.78 | KDM4E (0.68) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL9835718 | 0.77 | MAPT (0.68) | ALDH1A1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL9794678 | 0.77 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL14470798 | 0.75 | APP (0.69) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL12450221 | 0.75 | APP (0.56) | ALDH1A1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL28603982 | 0.74 | KDM4E (0.62) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL5053005 | 0.74 | KDM4E (0.62) | ALDH1A1HPGDKDM4EKDM6BKDM4A | |
| SCHEMBL11815860 | 0.73 | APP (0.66) | ALDH1A1KDM4EKDM6BKDM4AKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | SAUNDERS JEFFREY O | 2009-03-05 | — | — | US | disclosed |
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | SAUNDERS JEFFREY O | 2009-03-05 | — | — | US | disclosed |
| US-7439249-B2 | Inhibitors of phosphatases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439249-B2 | Inhibitors of phosphatases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-21 | — | — | US | disclosed |
| EP-1583747-A2 | INHIBITORS OF PHOSPHATASES | Vertex Pharmaceuticals Incorporated (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20040186116-A1 | such as 2-(7-acetylamino-1-furano-2-ylmethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-succinic acid; for treatment of autoimmune diseases, proliferative diseases, angiogenic disorders, and/or cancers; catheters, prosthetics | VERTEX PHARMACEUTICALS INCORPORATED | 2004-09-23 | — | — | US | disclosed |
| WO-2004060878-A2 | INHIBITORS OF PHOSPHATASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | PPM1G, PPM1A, PPM1F | ALDH1A1 3240/4885HPGD 2602/4885KDM4E 1488/4885 |
| US-20040186116-A1 | such as 2-(7-acetylamino-1-furano-2-ylmethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-succinic acid; for treatment of autoimmune diseases, proliferative diseases, angiogenic disorders, and/or cancers; catheters, prosthetics | CD47, FGF1, FGF2 | ALDH1A1 390/4885HPGD 245/4885KDM4E 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.