Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | CNR2 | P34972 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192268 | 0.87 | CNR1 (0.58) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL5226149 | 0.86 | MEN1 (0.55) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL5223032 | 0.85 | CNR1 (0.60) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4200262 | 0.85 | MEN1 (0.56) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4194283 | 0.84 | CNR1 (0.62) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4204512 | 0.84 | HTT (0.55) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4197464 | 0.81 | CNR1 (0.61) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL1308410 | 0.81 | GFER (0.76) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4199317 | 0.79 | CNR1 (0.73) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL25247976 | 0.78 | ALDH1A1 (0.66) | KMT2AMEN1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |