Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.62 |
| ▸ | CNR2 | P34972 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192268 | 0.88 | CNR1 (0.58) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4186581 | 0.84 | CNR1 (0.62) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL5223032 | 0.82 | CNR1 (0.60) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL5226149 | 0.78 | MEN1 (0.55) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4190780 | 0.77 | CNR1 (1.00) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4200262 | 0.77 | MEN1 (0.56) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4204512 | 0.76 | HTT (0.55) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4194303 | 0.76 | CNR1 (0.90) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL4197464 | 0.75 | CNR1 (0.61) | CNR1CNR2KMT2AMEN1RAB9A | |
| SCHEMBL487910 | 0.75 | EPHX2 (0.56) | KMT2AALDH1A1NPSR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |