Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 4/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200262 | 0.90 | MEN1 (0.56) | LMNAMEN1KMT2ARAB9ACNR1 | |
| SCHEMBL5226149 | 0.87 | MEN1 (0.55) | LMNAMEN1KMT2ARAB9ACNR1 | |
| SCHEMBL5258790 | 0.87 | HTT (0.70) | HTTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL5261323 | 0.85 | HTT (0.62) | HTTLMNAMEN1KMT2ACNR1 | |
| SCHEMBL4186581 | 0.84 | CNR1 (0.62) | LMNAMEN1KMT2ARAB9ACNR1 | |
| SCHEMBL4195045 | 0.81 | MEN1 (0.57) | HTTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL5223032 | 0.80 | CNR1 (0.60) | LMNAMEN1KMT2ARAB9ACNR1 | |
| SCHEMBL17554166 | 0.77 | BCL3 (0.73) | HTTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL4192268 | 0.76 | CNR1 (0.58) | LMNAMEN1KMT2ARAB9ACNR1 | |
| SCHEMBL4194283 | 0.76 | CNR1 (0.62) | LMNAMEN1KMT2ARAB9ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |