SCHEMBL4187360

SCHEMBL4187360

C=CC(=O)OCCc1cc(C(C)(C)C)cc(-n2nc3ccccc3n2)c1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.38
NPC1 O15118 5/20 0.36
RAB9A P51151 5/20 0.36
POLB P06746 2/20 0.35
ALOX5 P09917 5/20 0.34
ALDH1A1 P00352 5/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
AKR1B10 O60218 1/20 0.33
AKR1B1 P15121 1/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32
MAPT P10636 2/20 0.31
HPGD P15428 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
TP53 P04637 2/20 0.31
TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4200837 0.89 NPC1 (0.31) THRBNPC1RAB9A
SCHEMBL20494554 0.89 ALOX5 (0.38) NPC1RAB9APOLBALOX5ALDH1A1
SCHEMBL7033730 0.87 ALOX5 (0.34) THRBNPC1RAB9APOLBALOX5
SCHEMBL29372447 0.86 NPC1 (0.48) THRBNPC1RAB9APOLBALOX5
SCHEMBL226076 0.86 NPC1 (0.48) THRBNPC1RAB9APOLBALOX5
SCHEMBL29372465 0.86 NPC1 (0.36) THRBNPC1RAB9APOLBALDH1A1
SCHEMBL106698 0.86 NPC1 (0.36) THRBNPC1RAB9APOLBALDH1A1
SCHEMBL31579004 0.83 THRB (0.41) THRBNPC1RAB9APOLBALOX5
SCHEMBL27503098 0.82 THRB (0.38) THRBNPC1RAB9APOLBALOX5
SCHEMBL23246318 0.82 NPC1 (0.47) NPC1RAB9APOLBALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1995056-B1 MULTILAYER BODY TEIJIN CHEMICALS LTD (JP) 2016-08-17 EP disclosed
EP-1516722-B1 ACRYLIC RESIN COMPOSITION, ORGANOSILOXANE RESIN COMPOSITION AND LAMINATES MADE BY USING THEM TEIJIN CHEMICALS LTD (JP) 2015-09-02 EP disclosed
US-8859099-B2 Laminate of an acrylic resin composition layer containing triazine based ultra-violet compounds and an organosiloxane resin composition layer TEIJIN CHEMICALS, LTD. (JP) 2014-10-14 US disclosed
US-8765891-B2 Laminate of an acrylic resin composition layer containing triazine based ultra-violet compounds and an organosiloxane resin composition layer TEIJIN CHEMICALS, LTD. (JP) 2014-07-01 US disclosed
US-20130165570-A1 LAMINATE OF AN ACRYLIC RESIN COMPOSITION LAYER CONTAINING TRIAZINE BASED ULTRA-VIOLET COMPOUNDS AND AN ORGANOSILOXANE RESIN COMPOSITION LAYER TEIJIN CHEMICALS, LTD. (JP) 2013-06-27 US disclosed
US-20130165557-A1 LAMINATE OF AN ACRYLIC RESIN COMPOSITION LAYER CONTAINING TRIAZINE BASED ULTRA-VIOLET COMPOUNDS AND AN ORGANOSILOXANE RESIN COMPOSITION LAYER TEIJIN CHEMICALS, LTD. (JP) 2013-06-27 US disclosed
US-8404349-B2 Laminate of an acrylic resin composition layer containing triazine based ultra-violet compounds and an organosiloxane resin composition layer TEIJIN CHEMICALS, LTD. (JP) 2013-03-26 US disclosed
EP-2511093-A1 Multilayer body Teijin Chemicals, Ltd. (JP) 2012-10-17 EP disclosed
US-20090104447-A1 Laminate TEIJIN CHEMICALS, LTD. (JP) 2009-04-23 US disclosed
EP-1995056-A1 MULTILAYER BODY Teijin Chemicals, Ltd. (JP) 2008-11-26 EP disclosed
US-7070859-B2 Acrylic resin composition organosiloxane resin composition and laminate comprising the same TEIJIN CHEMICALS, LTD. (JP) 2006-07-04 US disclosed
EP-1516722-A1 ACRYLIC RESIN COMPOSITION, ORGANOSILOXANE RESIN COMPOSITION AND LAMINATES MADE BY USING THEM Teijin Chemicals, Ltd. (JP) 2005-03-23 EP disclosed
US-20040247878-A1 Acrylic resin composition organosiloxane resin composition and laminate comprising the same TEIJIN CHEMICALS LTD. (JP) 2004-12-09 US disclosed