Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | PLK4 | O00444 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638970 | 0.80 | FGFR1 (0.35) | SGK1TP53PLK4HTR2CHTR2A | |
| SCHEMBL24348512 | 0.70 | HTR2C (0.39) | SGK1PLK4HTR2CHTR2APAK4 | |
| SCHEMBL4199881 | 0.68 | CYP1A2 (0.32) | — | |
| SCHEMBL4201049 | 0.67 | TGFBR1 (0.32) | TP53LMNAPOLB | |
| SCHEMBL4196477 | 0.67 | JAK2 (0.39) | SGK1TP53LMNAFGFR1FGFR2 | |
| SCHEMBL24349703 | 0.67 | ACHE (0.44) | SGK1PLK4HTR2CHTR2APAK4 | |
| SCHEMBL30406140 | 0.67 | HTR2C (0.37) | SGK1PLK4HTR2CHTR2APAK4 | |
| SCHEMBL24348566 | 0.67 | HTR2C (0.37) | SGK1PLK4HTR2CHTR2APAK4 | |
| SCHEMBL30536612 | 0.66 | FGFR1 (0.39) | PLK4RAF1BRAFFGFR1FGFR2 | |
| Hydrochloric Acid SCHEMBL4200853 | 0.66 | JAK2 (0.32) | SGK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648455-A4 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1648455-A2 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009389-A2 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |