Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2968626 | 0.83 | NPC1 (0.41) | KCNH2KDM4EL3MBTL1MAPTGAA | |
| SCHEMBL28812235 | 0.83 | IDO1 (0.40) | KCNH2MAPTJAK2LMNAGAA | |
| SCHEMBL17046388 | 0.81 | L3MBTL1 (0.40) | KCNH2KDM4EL3MBTL1MAPTJAK2 | |
| SCHEMBL2971838 | 0.81 | CYP1A2 (0.49) | KCNH2L3MBTL1MAPTLMNAMEN1 | |
| SCHEMBL920555 | 0.79 | KDM4E (0.35) | KDM4EL3MBTL1MAPTJAK2LMNA | |
| SCHEMBL20797097 | 0.79 | HTR7 (0.51) | KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9532654 | 0.78 | DRD1 (0.38) | — | |
| SCHEMBL1069301 | 0.78 | ALDH1A1 (0.44) | KDM4EL3MBTL1MAPTLMNAGAA | |
| SCHEMBL20797181 | 0.76 | DRD3 (0.49) | KCNH2KDM4EMAPTLMNAMEN1 | |
| SCHEMBL9732356 | 0.75 | ALDH1A1 (0.56) | MAPTLMNAGAAMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466678-B | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH CORP | 2012-12-26 | — | — | CN | disclosed |
| CN-101466678-A | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH CORP (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-101454287-A | Substituted cyanopyridines as protein kinase inhibitors | WYETH CORP (US) | 2009-06-10 | — | — | CN | disclosed |
| EP-2027093-A2 | SUBSTITUTED CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007146323-A2 | SUBSTITUTED CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |