Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.81 |
| ▸ | HEXB | P07686 | 6/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | AHR | P35869 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | RGS12 | O14924 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329487 | 0.95 | HEXA (0.78) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL11678428 | 0.93 | HEXA (0.76) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL11807201 | 0.93 | HEXA (0.76) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL4997995 | 0.89 | HEXA (1.00) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9626265 | 0.89 | HEXA (0.83) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9290382 | 0.89 | HEXA (0.64) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9625779 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9625535 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9625518 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2AMEN1POLB | |
| SCHEMBL9625395 | 0.87 | HEXA (0.81) | HEXAHEXBKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107698571-B | Naphthalimide-coumarin DNA targeting double-intercalator, synthesis and application thereof | 大连理工大学 | 2020-07-14 | — | — | CN | claimed |
| CN-107698571-A | Naphthalimide-coumarin DNA targeting double-intercalator, synthesis and application thereof | 大连理工大学 | 2018-02-16 | — | — | CN | claimed |
| US-4006238-A | Use of 2-(hydroxyalkyl)-1H-benz[de]isoquinoline-1,3(2H)-diones as anti-allergy agents | E. R. SQUIBB & SONS, INC. (US) | 1977-02-01 | — | — | US | claimed |
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2022-05-12 | — | — | US | disclosed |
| EP-3902788-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | Istanbul Medipol Universitesi (TR) | 2021-11-03 | — | — | EP | disclosed |
| CN-107698571-B | Naphthalimide-coumarin DNA targeting double-intercalator, synthesis and application thereof | 大连理工大学 | 2020-07-14 | — | — | CN | disclosed |
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |
| CN-110931583-A | Packaging material and module structure | 财团法人工业技术研究院 | 2020-03-27 | — | — | CN | disclosed |
| US-20200098940-A1 | ENCAPSULATION MATERIAL AND MODULE STRUCTURE | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2020-03-26 | — | — | US | disclosed |
| CN-108727264-A | The preparation method and combinations thereof of naphthalimide diester fluorescent dye | 斯佩特罗尼克斯公司 | 2018-11-02 | — | — | CN | disclosed |
| WO-2018106200-A1 | ORIGINAL DRUG MOLECULES FOR THE TREATMENT OF PARASITIC AND NEOPLASTIC DISEASES AND METHODS FOR PREPARATION THEREOF | T.C MEDİPOL ÜNİVERSİTESİ (TR) | 2018-06-14 | — | — | WO | disclosed |
| EP-2029545-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | Universidade Do Porto (PT) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008007262-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIVERSIDADE DO PORTO (PT) | 2008-01-17 | — | — | WO | disclosed |
| US-5747206-A | Electrophotographic photoreceptor | FUJI XEROX CO., LTD. (JP) | 1998-05-05 | — | — | US | disclosed |
| WO-1995013817-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-4006238-A | Use of 2-(hydroxyalkyl)-1H-benz[de]isoquinoline-1,3(2H)-diones as anti-allergy agents | E. R. SQUIBB & SONS, INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-3940397-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-02-24 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | NPM1, ECI1, IPO5 | HEXA 2765/4885HEXB 2886/4885KMT2A 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.