SCHEMBL4188022

SCHEMBL4188022

C[C@@H](CC1CCCC1)NCc1ccccc1NS(=O)(=O)c1nnc(N)s1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
PKM P14618 1/20 0.39
MAPT P10636 8/20 0.35
TP53 P04637 3/20 0.35
POLB P06746 5/20 0.33
KMT2A Q03164 5/20 0.33
LMNA P02545 2/20 0.33
GAA P10253 2/20 0.32
ALDH1A1 P00352 2/20 0.32
CA2 P00918 2/20 0.31
CA9 Q16790 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MEN1 O00255 4/20 0.31
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4197348 0.99 KDM4E (0.40) KDM4EPKMMAPTTP53POLB
SCHEMBL4192474 0.84 MAPT (0.48) MAPTTP53POLBKMT2ALMNA
SCHEMBL4204383 0.83 KDM4E (0.40) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4189896 0.81 MEN1 (0.38) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4201910 0.81 CNR1 (0.41) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4199676 0.81 KDM4E (0.40) KDM4EPKMMAPTTP53POLB
SCHEMBL4199567 0.81 KDM4E (0.52) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4184516 0.80 KDM4E (0.53) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4204377 0.80 KDM4E (0.43) KDM4EPKMMAPTPOLBKMT2A
SCHEMBL4195035 0.80 KDM4E (0.46) KDM4EPKMMAPTTP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 KDM4E 3328/4885PKM 1855/4885MAPT 2269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.