HARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29733055	1.00	1/20
SCHEMBL3187637	0.75	1/20
SCHEMBL3187665	0.75	1/20
SCHEMBL4313369	0.75	1/20
SCHEMBL21067959	0.75	1/20
SCHEMBL21068060	0.75	1/20
Phesa (SCHEMBL3499217)	0.74	1/20
Phesa (SCHEMBL3499221)	0.74	1/20
SCHEMBL178823	0.73	1/20
SCHEMBL178824	0.73	1/20
SCHEMBL30270578	0.73	1/20
SCHEMBL4321355	0.73	1/20
SCHEMBL13773209	0.72	1/20
SCHEMBL13773210	0.72	1/20
SCHEMBL13773211	0.72	1/20
Leusa (SCHEMBL29562511)	0.72	1/20
Adenosine Phosphate (SCHEMBL15670732)	0.72	1/20
SCHEMBL3500697	0.71	1/20
SCHEMBL5063184	0.71	1/20
SCHEMBL5063189	0.71	1/20

Clinical trials — most relevant to HARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Personalized Antisense Oligonucleotide for A Single Participant With PACS1 Gene Mutation Associated With Schuurs-Hoeijmakers Syndrome (SHMS)	PHASE1/PHASE2	NOT_YET_RECRUITING
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Genetic Analysis of Fraser Syndrome and Fryns Syndrome	nan	COMPLETED
Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions	nan	WITHDRAWN
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism	nan	COMPLETED
Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients	nan	COMPLETED
French National Cohort of Patients With PRSS1 Mutations	nan	RECRUITING
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Genomic of CONgenital Sideroblastic Anemias	nan	RECRUITING
Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Genetic Analysis of Familial Hypertrophic Cardiomyopathy	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease	nan	UNKNOWN
Aswan Heart Centre - Egyptian Healthy Volunteers	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a HARS1 binder may also engage these)

Protein	Name	Similarity
Q5R4R2	—	1.000	Q5R4R2 →
Q2KI84	—	1.000	Q2KI84 →
Q61035	—	1.000	Q61035 →
E9QI36	—	0.989	E9QI36 →
P70076	—	0.984	P70076 →
P07178	—	0.978	P07178 →
A5D7V9	—	0.968	A5D7V9 →
Q5R5E5	—	0.965	Q5R5E5 →
P49590	—	0.963	P49590 →
Q86AS6	—	0.961	Q86AS6 →
P19356	—	0.961	P19356 →
Q5R514	—	0.960	Q5R514 →
Q99KK9	—	0.960	Q99KK9 →
Q29554	—	0.959	Q29554 →
Q6DIJ1	—	0.959	Q6DIJ1 →
Q7ZX51	—	0.959	Q7ZX51 →
O43011	—	0.959	O43011 →
Q5M7W7	—	0.958	Q5M7W7 →
P22907	—	0.958	P22907 →
HMBS	Porphobilinogen deaminase	0.958	landscape →
Q9YH58	—	0.958	Q9YH58 →
Q64428	—	0.958	Q64428 →
HADHA	Trifunctional enzyme subunit alpha, mitochondrial	0.957	landscape →
P13439	—	0.956	P13439 →
Q8BIP0	—	0.956	Q8BIP0 →
P32296	—	0.956	P32296 →
Q8BMF3	—	0.955	Q8BMF3 →
Q6PI48	—	0.955	Q6PI48 →
P28227	—	0.955	P28227 →
Q5R4A0	—	0.955	Q5R4A0 →