SCHEMBL4188639

SCHEMBL4188639

CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(CN(C)C(=O)CCCC)c1

nearest known ligand 0.71

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 10/20 0.66
CYP2C9 P11712 1/20 0.66
CYP2B6 P20813 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17781897 0.92 AGTR2 (0.66) AGTR2CYP2C9CYP2B6
SCHEMBL4183361 0.92 AGTR2 (0.68) AGTR2CYP2C9CYP2B6
SCHEMBL6823393 0.91 AGTR2 (0.71) AGTR2
SCHEMBL4183014 0.91 AGTR2 (0.64) AGTR2CYP2C9CYP2B6
SCHEMBL4192598 0.91 AGTR2 (0.64) AGTR2CYP2C9CYP2B6
SCHEMBL4192674 0.89 AGTR2 (0.64) AGTR2CYP2C9CYP2B6
SCHEMBL17781906 0.89 AGTR2 (0.68) AGTR2CYP2C9CYP2B6
SCHEMBL4190385 0.88 AGTR2 (0.67) AGTR2CYP2C9CYP2B6
SCHEMBL4187910 0.87 AGTR2 (0.69) AGTR2CYP2C9CYP2B6
SCHEMBL17781911 0.86 AGTR2 (0.66) AGTR2CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869009-B1 NEW BICYCLIC ANGIOTENSIN II AGONISTS VICORE PHARMA AB (SE) 2016-06-01 EP claimed
EP-1869009-B1 NEW BICYCLIC ANGIOTENSIN II AGONISTS VICORE PHARMA AB (SE) 2016-06-01 EP disclosed
US-8357710-B2 Bicyclic angiotensin II agonists VICORE PHARMA AB (SE) 2013-01-22 US disclosed
US-20090069382-A1 Bicyclic Angiotensin II Agonists VICORE PHARMA AB (SE) 2009-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069382-A1 Bicyclic Angiotensin II Agonists AGTR2, AGTR1, BDKRB2 AGTR2 1/4885CYP2C9 1592/4885CYP2B6 1317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.