Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28092443 | 0.83 | HPGD (0.59) | ALDH1A1MAPTMEN1KMT2AAR | |
| SCHEMBL9343281 | 0.83 | MEN1 (0.46) | ALDH1A1MAPTMEN1KMT2AAR | |
| SCHEMBL678299 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2AAR | |
| SCHEMBL4781334 | 0.77 | ALDH1A1 (0.72) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL5692501 | 0.76 | HSD17B10 (0.86) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL28069767 | 0.76 | HSD17B10 (0.86) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL301493 | 0.76 | HSD17B10 (1.00) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL3003404 | 0.76 | HSD17B10 (1.00) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL1619083 | 0.76 | HSD17B10 (1.00) | ALDH1A1MAPTMEN1KMT2AAR | |
| Diphenylamine SCHEMBL229 | 0.76 | HSD17B10 (1.00) | ALDH1A1MAPTMEN1KMT2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1014061-B | The preparation method of pyrimidine derivatives | ICI PLC (GB) | 1991-09-25 | — | — | CN | claimed |
| CN-1030412-A | PYRIMIDINE DERIVATIVES | ICI PLC (GB) | 1989-01-18 | — | — | CN | claimed |
| EP-0295839-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-21 | — | — | EP | claimed |
| US-4762835-A | INSECTICIDES, MITICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-08-09 | — | — | US | claimed |
| CN-86108825-A | PYRIMIDINE DERIVATIVES | — | 1987-07-22 | — | — | CN | claimed |
| EP-0227415-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-01 | — | — | EP | claimed |
| JP-56039043-A | — | — | None | — | — | JP | disclosed |
| US-20090111793-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-04-30 | — | — | US | disclosed |
| US-7423033-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080132482-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-06-05 | — | — | US | disclosed |
| US-7342008-B2 | Containing a benzodiazepine ring; 2-Cyclopentylmethyl-3(S)-hydroxyl-1-oxo-5-phenylpentyl)amino-1-methyl-5-(4-fluoro-phenyl)-2,3-dihydro-1H-1,5-benzodiazepin-2-one; Alzheimer's disease and Down's Syndrome; prevent the formation of neurological deposits of amyloid protein | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-03-11 | — | — | US | disclosed |
| US-20070027132-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Alphabeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-02-01 | — | — | US | disclosed |
| US-7112583-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-09-26 | — | — | US | disclosed |
| EP-0317265-A2 | Novel imidate insecticides | ZENECA INC. (US) | 1989-05-24 | — | — | EP | disclosed |
| CN-1030412-A | PYRIMIDINE DERIVATIVES | ICI PLC (GB) | 1989-01-18 | — | — | CN | disclosed |
| EP-0295839-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-21 | — | — | EP | disclosed |
| US-4762835-A | INSECTICIDES, MITICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-08-09 | — | — | US | disclosed |
| CN-86108825-A | PYRIMIDINE DERIVATIVES | — | 1987-07-22 | — | — | CN | disclosed |
| EP-0227415-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-01 | — | — | EP | disclosed |
| JP-S5639043-A | CYCLOPROPANECARBOXYLIC ACID ESTER AND INSECTICIDE AND MITICIDE | NIPPON SODA CO LTD | 1981-04-14 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027132-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Alphabeta protein production | APP, BACE1, APH1A | ALDH1A1 1954/4885MAPT 37/4885MEN1 1615/4885 |
| US-20080132482-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | APP, BACE1, APH1A | ALDH1A1 2275/4885MAPT 19/4885MEN1 1606/4885 |
| US-20090111793-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | APP, BACE1, APH1A | ALDH1A1 2275/4885MAPT 19/4885MEN1 1606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.