Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 9/20 | 0.37 |
| ▸ | ADH1C | P00326 | 6/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11592746 | 0.97 | ADH1A (0.36) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL28571319 | 0.78 | ADH1A (0.40) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL3364682 | 0.75 | ALDH1A1 (0.48) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL2635509 | 0.74 | ADH1A (0.37) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL1535264 | 0.74 | ADH1A (0.41) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL6057625 | 0.74 | CA1 (0.41) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL11455929 | 0.72 | TSHR (0.35) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL25477044 | 0.70 | ADH1A (0.36) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL14204958 | 0.70 | ADH1A (0.38) | ADH1AADH1CADH1BKDM4EMEN1 | |
| SCHEMBL14606330 | 0.70 | KDM4E (0.33) | ADH1AADH1CADH1BKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249908-A1 | USE OF NON-TOXIC POLYAMINE ANALOGUES AND/OR INHIBITORS OF POLYAMINE BIOSYNTHESIS TO RE-BALANCE NATURAL POLYAMINE LEVELS IN SNYDER-ROBINSON SYNDROME AND RELATED DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-12-28 | — | — | WO | claimed |
| EP-1357881-A4 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK PHARMACEUTICALS INC (US) | 2009-02-18 | — | — | EP | claimed |
| US-20040229886-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK BIOTECH, INC. & SHIONOGI CO., LTD. | 2004-11-18 | — | — | US | claimed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | claimed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | claimed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | claimed |
| WO-2023249908-A1 | USE OF NON-TOXIC POLYAMINE ANALOGUES AND/OR INHIBITORS OF POLYAMINE BIOSYNTHESIS TO RE-BALANCE NATURAL POLYAMINE LEVELS IN SNYDER-ROBINSON SYNDROME AND RELATED DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-12-28 | — | — | WO | disclosed |
| WO-2017136533-A1 | METHODS FOR TREATING DIAGNOSING, AND MONITORING TREATMENT OF MUCOPOLYSACCHARIDOSES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-08-10 | — | — | WO | disclosed |
| EP-1357881-A4 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK PHARMACEUTICALS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-20040229886-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK BIOTECH, INC. & SHIONOGI CO., LTD. | 2004-11-18 | — | — | US | disclosed |
| CN-1525818-A | Spermidine synthase inhibitors for the treatment of osteoarthritis and cartilage repair | ��ϣŵ | 2004-09-01 | — | — | CN | disclosed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | disclosed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | disclosed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | disclosed |