Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | INMT | O95050 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | QDPR | P09417 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711878 | 0.65 | CHRNB2 (0.38) | MEN1KMT2A | |
| SCHEMBL17555020 | 0.64 | INMT (0.31) | INMT | |
| SCHEMBL4768192 | 0.60 | HRH4 (0.37) | SLC18A3SIGMAR1GABRA1GABRG2GABRB3 | |
| SCHEMBL22755811 | 0.59 | SLC18A3 (0.40) | SLC18A3SIGMAR1GABRA1GABRG2GABRB3 | |
| SCHEMBL24067500 | 0.59 | SLC18A3 (0.64) | SLC18A3SIGMAR1GABRA1GABRG2GABRB3 | |
| SCHEMBL3764762 | 0.59 | — | — | |
| SCHEMBL24067526 | 0.57 | SLC18A3 (0.42) | SLC18A3SIGMAR1GABRA1GABRG2GABRB3 | |
| SCHEMBL5542721 | 0.54 | HTR1A (0.42) | SLC18A3SIGMAR1HTR2CMAPTTHRB | |
| SCHEMBL18763487 | 0.54 | — | — | |
| SCHEMBL17102937 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027116-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007139816-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-06 | — | — | WO | disclosed |