Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044549 | 0.88 | LMNA (0.58) | LMNAPOLBHPGDMEN1CYP3A4 | |
| SCHEMBL31202616 | 0.83 | SMN1; SMN2 (0.46) | LMNAHPGDMEN1MAPTKMT2A | |
| SCHEMBL3953274 | 0.83 | NMT2 (0.46) | POLB | |
| SCHEMBL32667549 | 0.83 | MEN1 (0.57) | POLBHPGDMEN1KMT2A | |
| SCHEMBL1477277 | 0.83 | GBA1 (0.50) | LMNAHPGDHRH1MEN1KMT2A | |
| SCHEMBL23086069 | 0.83 | EPHX2 (0.52) | PIK3CA | |
| Hydrochloric Acid SCHEMBL1475977 | 0.82 | NMT2 (0.46) | POLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9310454 | 0.81 | GBA1 (0.49) | LMNAHPGDHRH1MEN1KMT2A | |
| SCHEMBL31693930 | 0.81 | DPP4 (0.44) | — | |
| SCHEMBL652791 | 0.78 | LMNA (0.79) | LMNAPOLBHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784401-A4 | UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-07-15 | — | — | EP | disclosed |
| EP-1784401-A1 | UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006024160-A1 | UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-03-09 | — | — | WO | disclosed |