Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSG | P08311 | 9/20 | 0.70 |
| ▸ | MASP2 | O00187 | 1/20 | 0.70 |
| ▸ | CMA1 | P23946 | 4/20 | 0.69 |
| ▸ | ACP3 | P15309 | 3/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181576 | 0.90 | CTSG (0.73) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL4191174 | 0.87 | CTSG (0.72) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL12523113 | 0.87 | CTSG (0.72) | CTSGMASP2CMA1ACP3 | |
| SCHEMBL1614762 | 0.84 | CTSG (0.82) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL1614349 | 0.83 | CTSG (0.80) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL31211813 | 0.82 | CTSG (1.00) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL1613660 | 0.82 | CTSG (1.00) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL1260969 | 0.81 | CTSG (1.00) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL30355342 | 0.81 | CTSG (1.00) | CTSGMASP2CMA1ACP3PTGDR2 | |
| SCHEMBL30583367 | 0.81 | CTSG (1.00) | CTSGMASP2CMA1ACP3PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247599-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-08-21 | — | — | US | claimed |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | claimed |
| EP-1438316-B1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO MCNEIL PHARM INC (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1438316-A1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-07-21 | — | — | EP | claimed |
| US-20040082544-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-04-29 | — | — | US | claimed |
| US-20030195172-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N (US) | 2003-10-16 | — | — | US | claimed |
| WO-2003035654-A1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-01 | — | — | WO | claimed |
| US-20090054319-A1 | Methods and Compositions for the Treatment of Hypertension and Gastrointestinal Disorders | MICROBIA, INC. (US) | 2009-02-26 | — | — | US | disclosed |
| WO-2006102069-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND GASTROINTESTINAL DISORDERS | MICROBIA, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082544-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | CTSG 251/4885MASP2 31/4885CMA1 137/4885 |
| US-20030195172-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | CTSG 251/4885MASP2 31/4885CMA1 137/4885 |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | CTSG 251/4885MASP2 31/4885CMA1 137/4885 |
| US-20090054319-A1 | Methods and Compositions for the Treatment of Hypertension and Gastrointestinal Disorders | PTGIS, PTGIR, GRPR | CTSG 1249/4885MASP2 3443/4885CMA1 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.