SCHEMBL4189859

SCHEMBL4189859

CC(NCc1ccccc1NS(=O)(=O)c1ccc(-n2cccc2)cc1)C(F)C1CCCCC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 5/20 0.52
KDM4E B2RXH2 3/20 0.52
LMNA P02545 5/20 0.42
POLB P06746 4/20 0.42
ALDH1A1 P00352 10/20 0.42
MEN1 O00255 7/20 0.42
KMT2A Q03164 7/20 0.42
MAPT P10636 7/20 0.42
HSD17B10 Q99714 1/20 0.40
HPGD P15428 1/20 0.39
BLM P54132 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
GAA P10253 2/20 0.37
MCOLN3 Q8TDD5 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HTT P42858 2/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4185861 0.90 PKM (0.51) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4188353 0.90 PKM (0.51) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4188350 0.90 PKM (0.51) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4185855 0.90 PKM (0.51) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4202288 0.84 PKM (0.50) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4201917 0.83 PKM (0.48) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4190735 0.79 PKM (0.50) PKMKDM4ELMNAALDH1A1MEN1
SCHEMBL4203662 0.78 NPC1 (0.48) PKMKDM4EALDH1A1MEN1KMT2A
SCHEMBL4186498 0.76 PKM (0.50) PKMKDM4ELMNAPOLBALDH1A1
SCHEMBL4708104 0.75 PKM (0.56) PKMKDM4ELMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
CN-101203504-B Antimicrobial agents RANBAXY LAB LTD 2012-11-14 CN claimed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
CN-101203504-A Antimicrobial agents RANBAXY LAB LTD (IN) 2008-06-18 CN claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
CN-101203504-B Antimicrobial agents RANBAXY LAB LTD 2012-11-14 CN disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed
CN-101203504-A Antimicrobial agents RANBAXY LAB LTD (IN) 2008-06-18 CN disclosed
EP-1879877-A2 ANTIMICROBIAL AGENTS Ranbaxy Laboratories Limited (IN) 2008-01-23 EP disclosed
WO-2006117762-A2 ANTIMICROBIAL AGENTS RANBAXY LABORATORIES LIMITED (IN) 2006-11-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 PKM 1855/4885KDM4E 3328/4885LMNA 2332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.